PD 168568 dihydrochloride

Research use only, not for human use.

PD 168568 dihydrochloride is an orally active and selective antagonist of D4 dopamine receptor(Ki of 8.8 nM).

PD 168568 dihydrochloride is an orally active and selective antagonist of D4 dopamine receptor(Ki of 8.8 nM).(In Vitro):PD 168568 dihydrochloride has good selective for D4 receptor(Ki of 1842 nM for D2 receptor).(In Vivo):PD 168568 dihydrochloride inhibit amphetamine stimulated locomotor activity in the rat.

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Animal Model:Rat Dosage:3 mg/kg Administration:Oral administration Result:Inhibit amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.

PD 168568 (dihydrochloride)

GPCR/G Protein

Dopamine Receptor

α4β2 nAChR| α7 nAChR

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1782532-06-2

422.39

C22H29Cl2N3O

>98% (HPLC)

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Cl.Cl.Cc1ccc(cc1C)N1CCN(CCC2NC(=O)c3ccccc23)CC1

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(-20℃)

With Ice Pack

≥ 2 years